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In general, benzodiazepines should be prescribed for short periods only (e.g. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving lorazepam or other psychotropic agents. The dependence potential is reduced when lorazepam is used at the appropriate dose for short-term treatment. The risk of dependence increases with higher doses and longer term use and is further increased in patients with a history of alcoholism or drug abuse or in patients with significant personality disorders. The use of benzodiazepines, including lorazepam, may lead to physical and psychological dependence. Use of benzodiazepines, including lorazepam, may lead to physical and psychological dependence.Īs with all patients on CNS-depressant drugs, patients receiving lorazepam should be warned not to operate dangerous machinery or motor vehicles and that their tolerance for alcohol and other CNS depressants will be diminished. (See PRECAUTIONS, Clinically Significant Drug Interactions) Use of benzodiazepines, including lorazepam, both used alone and in combination with other CNS depressants may lead to potentially fatal respiratory depression.
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Lorazepam is not recommended for use in patients with a primary depressive disorder or psychosis. Pre-existing depression may emerge or worsen during use of benzodiazepines including lorazepam.